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Impact of gut microbiota on cancer therapy outcomes

It is well recognized that gut microbiota shapes human immunity and plays important roles in regulating nearly all aspects of human disease development. The literature also suggests that antibiotic administration may lead to worse side-effects in patients treated with cancer therapy.
In this project, we aim to understand how the disruption of gut microbiota can lead to local tissue damage and contribute to increased side-effects of cancer therapy in pre-clinical mouse models.