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Drugging the undruggable – new approaches for targeting transcription factors

Transcription factors are the master regulators of cell state and, as a result, they play a fundamental role in disease. Despite their importance, transcription factors have traditionally remained largely refractory to therapeutic targeting. This project will leverage recent advances in CRISPR and mRNA technology to attempt to understand, then disrupt, the regions required for transcription factor activity. This could open up a new class of drugs that enable us to control the factors that control the identify of our cells.